tetramethylbenzene , also known as 1,2,3, 4-tetramethylbenzene or homotetramethylbenzene, is an organic compound with the formula C8H10 and molecular weight 114.18. It is a commonly used organic solvent with low volatility and high chemical stability. Tetramethylbenzene is a colorless transparent liquid at room temperature and pressure. It is insoluble in water but soluble in common organic solvents such as ethyl acetate and methylene chloride Tetramethylbenzene has high chemical stability and is not prone to various chemical reactions. It can undergo Fouck alkylation or Fouck acylation under the action of Lewis acid catalyst. In addition, the benzyl carbon atoms in the structure can be brominated under the action of brominating reagents to form the corresponding benzyl bromide derivatives Colorless transparent liquid at room temperature and pressure, it is a toluene derivative with extremely high chemical stability, it is insoluble in water but soluble in common organic solvents including ethyl acetate, methylene chloride and so on. 1,2,3, 4-tetrmethyl benzene has similar physical and chemical properties to toluene, and it shows good solubility to many organic compounds. It is commonly used as a non-polar organic solvent in the field of organic synthesis, and has certain applications in the basic research field of organic methodology.