In the first industrial production, a mixture of sugar aldehyde and vapor was passed into a reactor filled with zinc-chromium-manganese metal oxide (or palladium) catalyst, and furan was decarbonylated at 400-420ºC, and then furan was hydrogenated to tetrahydrofuran at 80-120ºC with skeleton nickel as catalyst. The production of 1 ton of tetrahydrofuran requires about 3 tons of polysaccharide aldehyde. There are many production methods developed later, the industrial method is 1, 4-butanediol catalytic dehydration ring method, because butanediol is prepared from acetylene and formaldehyde, this method is called the Reppe method, using 1, 4-dichlorobutadiene, a byproduct of the neoprene monomer chloroprene to produce tetrahydrofuran, In recent years, a catalytic hydrogenation process using maleic anhydride as raw material has been developed.
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