It is prepared by pressurized catalytic hydrogenation of phenylacetonitrile. The liquid ammonia is passed into phenylacetonitrile, cooled and absorbed, mixed with Rainey nickel and added to the autoclave to remove air and dissipate hydrogen. Reaction at about 10MPa at 80-120ºC for 3h until hydrogen is no longer absorbed, cooling pressure relief, filtration. The filtrate was distilled under vacuum, and the fraction of 90-93ºC (2kPa) was collected, that is, 2-phenylethylamine. The yield is 90%. For the preparation of 2-phenylethylamine hydrochloride (156-28-5), take the filtrate, adjust it with hydrochloric acid below 60ºC to a pH of 3-4, cool it to 5ºC, stand for 8h, and filter it. The carbonate is a flake crystal. Melting point 223-224ºC (217ºC)
Uses Phenylethylamine is an important pharmaceutical and dye intermediate, which is mainly used in medicine to synthesize penicillin benzylamine and hypoglycemic drugs. An intermediate of the drug hypoglycin, also used in other organic synthesis. Products such as glipizide can be produced using β-phenylethylamine.
Density 1.0± 0.1g /cm3Boiling point 183.0±9.0 °C at 760 mmHgMelting point -65ºCMolecular formula C8H11NMolecular weight 121.180Flash point 79.4±0.0 °CAccurate mass 121.089149PSA 26.02000LogP is 1.44Vapor pressure 0.8±0.3 mmHg at 25°CRefractive index 1.533Storage condition
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