Organic Intermediate CAS: 118864-75-8 Solifenacinepimpuritya (1S) -1-Phenyl-1 2 3

• CAS No.: 118864-75-8
• Formula: C15h15n
• EINECS: 202-050-0
• Model NO.: 1, 2, 3, 4-TETRAHYDROISOQUINOLINE
• Type: Synthesis Material Intermediates
• Appearance: Solid
• Quality: Industrial
• Colour: White
• Melting Point: 80-82°c
• Boiling Point: 338°c
• Density: 1.065
• Form: Solid
• Color: White
• Transport Package: Barrel
• Specification: 200kg
• Trademark: DeXiang
• Origin: China
• HS Code: 2933497000
• Production Capacity: 100000piceces/Year

Product Description

Product Description

Application

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline can be used to prepare solifenacin. Solifenacin Succinate, CAS No. 242478-38-2, chemical name 1-azabicyclo[2.2.2]octane-8-yl-(1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate succinate, is a selective muscarinic M3 receptor antagonist developed by Astellas Corporation of Japan. It was first launched in the Netherlands, Germany, the United Kingdom and Denmark in 2004, and in China in 2009. So far, it has been launched in more than 50 countries and regions around the world. It has become an important drug for the treatment of overactive bladder (OAB) in the European, American and Japanese markets, and is recommended by many authoritative organizations and guidelines. The preparation method is as follows: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (I) is reacted with triphosgene under organic base (weak base) conditions to obtain (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride (II); compound II can be directly heated under the catalysis of an organic base through a one-pot method without separation, and condensed with (R)-3-quinuclidine alcohol to obtain solifenacin (III), and then salified with succinic acid to obtain solifenacin succinate (IV).

 
 

Product Parameters

 

 

Company Profile

 

FAQ

1 Q:Are you manufacturer?
A: Yes, we are a factory over 5 years and our products sales well on the market.

2 Q: What is your MOQ?
A: Our MOQ is at least 1 One package.

3 Q: What kind of package do you have?
A: We have various of packages to meet our customers,like Iron drums,plastic drums, IBC tanks,  ISO TANK and bags etc.

4 Q :Which kind of payment terms do you accept?
A:We prefer TT payment terms. Other payment terms are flexible to be further discussed.

5 Q: Can I get a sample?
A: Free samples are available, but buyers needs to pay freight.
But for high value item, should pay sample cost.

6 Q: How long does it take for me to get a sample?
A: It depends. Generally speaking, it is about 7-10 days.

7 Q: Why is the quote offered different from the sticker price?
A: As we know, prices of chemicals are not fixed, they fluctuate with the markets.

8 Q:Can you give me a discount price?
A: Yes. It depends on your order quantity.

9 Q: How about your delivery? When will my goods be shipped?
A: Prompt and reliable delivery by professional shipping lines.
About 3-5 days after prepayment is done.

10 Q: Is the quality of your products guaranteed? 
A: We have a professional R&D team, so every batch of our products is up to standard. We will have goods tested and provide COA before delivery for sure.