Isopropyl inosine is a 1:3 compound composed of inosine and dimethylamine isopropyl acetaminobenzoate. It is a chemical synthetic immunomodulator and is used in the pharmaceutical industry for the treatment of viral diseases such as influenza virus, herpes virus and immunodeficiency virus. The main pharmacological effects of isopropyl inosine are as follows: (1) isopropyl inosine can promote lymphocyte proliferation induced by phytohemagglutinin (PHA), canavalin A(ConA), tetanus toxoid and influenza virus. (2) Enhance the delayed allergic reaction caused by dinitrochlorobenzene, and restore the delayed allergic reaction inhibited by cyclophosphamide to normal. (3) Restoring the proliferative response of cyclophosphamide-inhibited mouse splenic lymphocytes to ConA. (4) This product can also promote the production of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon, and enhance the activity of mononuclear macrophages and natural killer cells (NK). It can also restore normal immune function caused by aging, including the decrease of lymphocyte proliferation response caused by aging, NK cytotoxicity, monocyte chemotaxis and the number of plaque forming cells can be restored to normal or near normal levels. Physical and chemical properties White powder, odorless, tasteless. Dissolve in water. mp81~83 ° C. Pharmacokinetics This product is absorbed and metabolized rapidly after oral or intravenous administration. The blood concentration reached the peak 1 hour after oral administration, and decreased to disappear 2 hours later. The main excreted Chemicalbook is uric acid, and other metabolites are excreted in urine after oxidation or gluconaldehyde acidification. The oral plasma half-life is 50 minutes and the intravenous half-life is 3 minutes. Antiviral effect Isopropyl inosine has antiviral effect and is effective against human herpes, influenza and nasal infection. It is effective in patients with herpes simplex virus infection. In addition to the direct antiviral effect, this product also has immune enhancement effect, mainly to enhance cellular immune function. Clinical studies have shown that it can increase the proliferation of lymphocytes caused by mitotic factors, increase the production of antibodies, and increase the production of cytokines such as interleukin-2. This product has the characteristics of high curative effect and small side effects. Indications isopropyl inosine is an antiviral drug that can increase peripheral blood lymphocytes, increase lymphocyte conversion rate, and increase IFN levels in children. The drug has been used in SSPE for nearly 20 years, and most studies have shown that the drug can improve or stabilize the symptoms of some children, improve the survival rate, and more than IFN combined. This product is mainly used for herpes simplex virus infection and genital warts, and can also improve the immune function of patients with primary tumors such as lung cancer, breast cancer and melanoma. Generally, immune function can be maintained for 2 months after each dose. Isopropyl inosine also has a certain effect on autoimmune diseases such as rheumatoid arthritis, including slowed sedimentation rate, decreased fibrinogen, reduced number of swollen joints, and reduced morning stiffness. It is also effective for multiple keratitis and focal genital inflammation.
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